Idiopathic headache disorders are the main cause of “Migraine” that is defined as an episodic disturbance which initially manifesting as head pain, touch sensitivity, and later on leads to nausea and light sensitivity. According to Neuroimaging study of the migraineurs it is described that the functional abnormalities in brain regions connected with pain processing as a result of repeated headache attacks, including enhanced cortical excitability and altered the pain modulatory systems. Regional homogeneity (ReHo) and functional interregional connectivity of brain were evaluated to determine the focal and global features of brain dysfunction in migraine.
The link between changes in headache parameters is reported in the patients as their headache activity increased over time. Unusual ReHo changes in the patient group relative to the HC were found in the putamen, orbitofrontal cortex, secondary somatosensory cortex, brainstem, and thalamus. Moreover, these brain regions exhibited longitudinal ReHo changes in migraine patients. These headache activity changes were accompanied by disproportionately dysfunctional connectivity in the putamen in the migraine patients, as shown by functional connectivity analysis, suggesting that the putamen plays an important role in integrating diverse information among other migraine-related brain regions.